tissue factor gene mutation

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The relationship between tissue factor and cancer ...- tissue factor gene mutation ,The primary initiator of coagulation, the transmembrane receptor tissue factor (TF), has gained considerable attention as a determinant of tumor progression. On complex formation with its ligand, coagulation factor VIIa, TF influences protease-activated receptor-dependent tumor …Tissue Factor Pathway Inhibitor - an overview ...Tissue factor pathway inhibitor (TFPI) is 32-kDa (276-amino-acid) plasma protein and a Kunitz-type protease inhibitor of factor Xa and tissue factor/factor VIIa catalytic activity. 370,371 The TFPI gene is located on the short arm of chromosome 2 (q32) and consists of nine exons spanning 70 kb. TFPI has a complex intravascular distribution.



Novel factor VII gene mutations in six families with ...

Aug 02, 2021·Abstract Introduction Hereditary human coagulation factor VII (FVII) deficiency is an inherited autosomal recessive hemorrhagic disease involving mutations in the F7 gene. The sites and types of F7...

Genetics: Breast Cancer Risk Factors

Apr 21, 2021·Inheriting an abnormal TP53 gene causes Li-Fraumeni syndrome, a disorder in which people develop soft tissue cancers at a young age. People with this rare syndrome have a higher-than-average-risk of breast cancer and several other cancers, including leukemia, brain tumors, and sarcomas (cancer of the bones or connective tissue).

Regulation of the Tissue Factor Gene in Human Monocytic ...

Feb 01, 1997·Regulation of tissue factor gene expression in the monocyte procoagulant response to endotoxin. Mol Cell Biol.. 1989; 9:2752-2755. Crossref Medline Google Scholar; 7 Brand K, Fowler BJ, Edgington TS, Mackman N. Tissue factor mRNA in THP-1 monocytic cells is regulated at both transcriptional and posttranscriptional levels in response to ...

EGFR Mutation Testing | Lab Tests Online

Mar 06, 2020·EGFR is a short name for the Epidermal Growth Factor Receptor gene. DNA from tumor cells is tested for mutations in this gene. In certain situations, DNA that has been shed from tumor cells in one’s blood can also be tested and may be informative (liquid biopsy).The EGFR gene provides instructions for a cell to make a specialized type of protein called a receptor, which is located on the ...

Genetic variation in the tissue factor gene is associated ...

Nov 17, 2014·Activation of inflammation and coagulation was closely related and mutually interdependent in sepsis. Tissue factor (TF) and its endogenous inhibitor, tissue factor pathway inhibitor (TFPI) was the main regulators of the initiation of coagulation process. Altered plasma levels of TF and TFPI have been related to worse outcome in sepsis. The objective of this study was to investigate whether ...

Association of Asn221Ser mutation in tissue factor pathway ...

Tissue factor pathway inhibitor (TFPI) is an anticoagulant protease inhibitor that inhibits the tissue factor-initiated blood coagulation cascade reactions. Based on these anticoagulant functions of TFPI, we hypothesized that genetic variations in TFPI may alter the TFPI expression or impair the anticoagulant function and could predispose persons to deep vein thrombosis (DVT).

(PDF) Author Correction: Structure-based design and ...

PDF | On Sep 7, 2021, Shuntaro Chiba and others published Author Correction: Structure-based design and discovery of novel anti-tissue factor antibodies with cooperative double-point mutations ...

Structure-based design and discovery of novel anti-tissue ...

Oct 16, 2020·Chiba, S., Tanabe, A., Nakakido, M. et al. Structure-based design and discovery of novel anti-tissue factor antibodies with cooperative double-point mutations, using interaction analysis.

Regulation of the tissue factor gene - Mackman - 1995 ...

Jul 01, 1995·The tissue factor (TF) gene is expressed in a cell type-specific manner in vivo. It is constitutively expressed by several extravascular cell types and indueibly expressed within the vasculature by monocytes and endothelial cells. TF expression initiates thrombotic episodes associated with various diseases, including atherosclerosis, septic ...

Tissue Factor - an overview | ScienceDirect Topics

Tissue factor is the only known cellular receptor for FVII and FVIIa. Tissue factor is a transmembrane glycoprotein with a 219-amino acid extracellular domain, a 23-residue transmembrane region, and a 21-residue intracellular domain. The lungs and central nervous system are known to contain high levels of TF activity.

F3 coagulation factor III, tissue factor [Homo sapiens ...

Jul 08, 2021·F3. coagulation factor III, tissue factor [. Homo sapiens. (human) ] This gene encodes coagulation factor III which is a cell surface glycoprotein. This …

Native and oxidized low density lipoprotein induction of ...

Tissue factor, in association with factor VIIa, initiates the coagulation cascade. We studied the influences of two pathophysiological stimuli, native (unmodified) and oxidized low density lipoprotein, on tissue factor gene expression in a cell important in vascular remodeling and vascular diseases, the smooth muscle cell.

Factor XII - Wikipedia

Factor XII. Coagulation factor XII, also known as Hageman factor, is a plasma protein. It is the zymogen form of factor XIIa, an enzyme ( EC 3.4.21.38) of the serine protease (or serine endopeptidase) class. In humans, factor XII is encoded by the F12 gene.

High Mutational Heterogeneity, and New Mutations in the ...

Factor V deficiency is an autosomal recessive coagulation disorder associated with mutations in the factor V gene. This hereditary coagulation disorder is clinically characterized by a heterogeneous spectrum of hemorrhagic manifestations ranging from mucosal or soft-tissue bleeds to potentially fatal hemorrhages.

(PDF) Tissue Factor and Extracellular Vesicles: Activation ...

Jul 30, 2021·Tissue factor expression in non-small cell lung cancer: Relationship with vascular endothelial growth factor expression, microvascular density , and K-ras mutation. J.

TGFBR2 gene: MedlinePlus Genetics

More than 100 mutations in the TGFBR2 gene have been found to cause Loeys-Dietz syndrome type II. Loeys-Dietz syndrome affects connective tissue, which gives structure and support to blood vessels, the skeleton, and other parts of the body. This type of Loeys-Dietz syndrome is characterized by blood vessel abnormalities and skeletal deformities.

BRCA Gene Mutations: Cancer Risk and Genetic Testing Fact ...

A woman’s lifetime risk of developing breast and/or ovarian cancer is markedly increased if she inherits a harmful variant in BRCA1 or BRCA2, but the degree of increase varies depending on the mutation.. Breast cancer: About 13% of women in the general population will develop breast cancer sometime during their lives ().By contrast, 55% – 72% of women who inherit a harmful BRCA1 variant ...

(PDF) Author Correction: Structure-based design and ...

PDF | On Sep 7, 2021, Shuntaro Chiba and others published Author Correction: Structure-based design and discovery of novel anti-tissue factor antibodies with cooperative double-point mutations ...

Influence of mutations in tissue factor on the fine ...

Feb 01, 1997·Analysis of the factor VIIa binding site on human tissue factor: effects of tissue factor mutations on the kinetics and thermodynamics of binding. Biochemistry. 1995 Aug 22; 34 (33):10383–10392. [Google Scholar] Fraker PJ, Speck JC., Jr Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a ...

Gene mutation, tissue location, signaling net | EurekAlert!

Sep 11, 2019·Gene mutation, tissue location, signaling networks drive cancer incidence and severity ... "The concept that no single factor can predict whether a cancer responds to a particular therapy will be ...

Antithrombin Deficiency Differential Diagnoses

Aug 22, 2019·Possible tissue factor pathway (TFPI) mutations/deficiency. Rare inherited defects in the fibrinolytic system (dysplasminogenemia, abnormal PAI-1, defective release of tissue-type plasminogen activator [tPA]) and elevated levels of alpha2-antiplasmin. Thrombomodulin gene mutations.

Author Correction: Structure-based design and discovery of ...

Sep 07, 2021·Author Correction: Structure-based design and discovery of novel anti-tissue factor antibodies with cooperative double-point mutations, using interaction analysis Shuntaro Chiba 1 , Aki Tanabe 2 ,

Regulation of Tissue Factor Gene Expression In Human ...

Mar 01, 2000·INTRODUCTION. Tissue factor (TF), the cell membrane-bound glycoprotein responsible for the initiation of hemostasis, is synthesized in several cell types (1– 3).Our prior studies demonstrated that TF is also expressed in human endometrial stromal cells (HESCs) where its expression is greatly enhanced by progestins in vitro and in vivo (4, 5).In contrast to the immediate and transient ...

Clinical and biological features associated with epidermal ...

Background: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these cancers to drugs that inhibit EGFR kinase activity. However, the role of such mutations in the pathogenesis of lung cancers is unclear. Methods: We sequenced exons 18-21 of the EGFR TK domain from genomic DNA isolated ...

Tfpi MGI Mouse Gene Detail - MGI:1095418 - tissue factor ...

J:41945 Huang ZF, et al., Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice. Blood. 1997 Aug 1;90(3):944-51 Blood. 1997 Aug 1;90(3):944-51 Latest

Is tissue factor factor 3?

Tissue factor, also called platelet tissue factor, factor III, or CD142, is a protein encoded by the F3 gene, present in subendothelial tissue and leukocytes. Its role in the clotting process is the initiation of thrombin formation from the zymogen prothrombin.