epicardial adipose tissue definition and function

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Epicardial and pericardial adipose tissues are associated ...- epicardial adipose tissue definition and function ,May 03, 2019·The aim of this study was to investigate the association of epicardial (EAT) and pericardial (PAT) adipose tissues with myocardial function in type 2 diabetes (T2D). EAT and PAT were measured by ultrasound in 770 patients with T2D and 234 age- and sex-matched non-diabetic controls.Epicardial adipose tissue (dys)function: A new player in ...Epicardial adipose tissue (EAT) is located between the visceral layer of the pericardium and the myocardium, while pericardial adipose tissue is located …



Adipose Tissue - Meaning, Types, Functions, and FAQs

The adipose tissue definition is as follows - it is a specialized connective tissue that helps in the storage of fat. These tissues are located in subcutaneous, intraabdominal, epicardial, and gonadal. These tissues are located in interscapular, perirenal, cervical, paravertebral and supraclavicular.

Epicardial adipose tissue: anatomic, biomolecular and ...

Epicardial adipose tissue is also clinically related to left ventricular mass and other features of the metabolic syndrome, such as concentrations of LDL cholesterol, fasting insulin and adiponectin, and arterial blood pressure. Echocardiographic assessment of epicardial fat could be a simple and practical tool for cardiovascular risk ...

Epicardial adipose tissue: far more than a fat depot

Nov 05, 2014·Definition of cardiac fat deposits. A variety of terms including ‘epicardial’, ‘pericardial’, ‘paracardial’ and ‘intra-thoracic’ have been used to describe adipose tissue deposits in proximity to the heart or within the mediastinum.

Epicardial adipose tissue: new parameter for ...

Apr 27, 2018·Epicardial adipose tissue (EAT) is localized between the myocardial surface and visceral layer of the pericardium. It is a metabolically active organ that secretes several cytokines which modulate cardiovascular morphology and function. EAT may interact locally with coronary arteries through paracrine secretion mechanisms. Cytokines from peri-adventitial EAT may pass through the coronary …

Epicardial adipose tissue: fuel for COVID-19-induced ...

May 28, 2020·Epicardial adipose tissue (EAT), located between the myocardium and visceral pericardium, is a unique fat depot with multifaceted features such as local and systemic physiological effects. 3 This tissue has the highest rates of lipogenesis and fatty acid metabolism among the visceral fat depots and displays metabolic, thermogenic, and ...

Cellular cross-talk between epicardial adipose tissue and ...

Oct 15, 2012·Epicardial and perivascular fat depot size is considered an index of cardiac and visceral obesity. The functional and anatomic proximity of epicardial adipose tissue (EAT) to myocardium has drawn increasing attention in recent years among researchers attempting to elucidate its putative role as an endocrine organ. This includes the role of EAT as a lipid storing depot and as an inflammatory ...

Epicardial adipose tissue in patients with heart failure ...

Jul 12, 2010·The aim of this study was to evaluate the extent of epicardial adipose tissue (EAT) and its relationship with left ventricular (LV) parameters assessed by cardiovascular magnetic resonance (CMR) in patients with congestive heart failure (CHF) and healthy controls. EAT is the true visceral fat deposited around the heart which generates various bioactive molecules.

Cellular cross-talk between epicardial adipose tissue and ...

Oct 15, 2012·Epicardial and perivascular fat depot size is considered an index of cardiac and visceral obesity. The functional and anatomic proximity of epicardial adipose tissue (EAT) to myocardium has drawn increasing attention in recent years among researchers attempting to elucidate its putative role as an endocrine organ. This includes the role of EAT as a lipid storing depot and as an inflammatory ...

Relationship between epicardial adipose tissue thickness ...

Feb 27, 2015·Epicardial adipose tissue (EAT) is metabolically bioactive fat [1–5], excessive accumulation of which can damage myocardium [5, 6].Left ventricular (LV) diastolic function has actually been shown to be impaired by accumulation of EAT in patients with preserved LV systolic function as defined by normal LV ejection fraction (EF) [5, 6].Early impairment of LV systolic function is present in ...

Epicardial Adipose Tissue: Relations to the Heart

Sep 11, 2021·Epicardial adipose tissue: A visceral fat depot around the heart, especially the right-ventricular free wall and left-ventricular apex, which generates various bioactive molecules

Epicardial adipose tissue in obesity-related cardiac ...

May 13, 2021·Epicardial adipose tissue (EAT) is a unique visceral fat in close proximity to the heart and is of particular interest to the study of cardiac disease. Small poorly differentiated adipocytes with altered lipid:water content are associated with a proinflammatory secretome and may contribute to the pathophysiology observed in HFpEF.

Epicardial adipose tissue: fuel for COVID-19-induced ...

May 28, 2020·Epicardial adipose tissue (EAT), located between the myocardium and visceral pericardium, is a unique fat depot with multifaceted features such as local and systemic physiological effects. 3 This tissue has the highest rates of lipogenesis and fatty acid metabolism among the visceral fat depots and displays metabolic, thermogenic, and ...

Epicardial Adipose Tissue: Relations to the Heart

Aug 30, 2021·Epicardial adipose tissue: A visceral fat depot around the heart, especially the right-ventricular free wall and left-ventricular apex, which generates various bioactive molecules

Association of Increased Epicardial Adipose Tissue ...

The thickness of epicardial adipose tissue (EAT) was reported to be highly associated with the incidence and severity of atrial fibrillation (AF). This study was conducted to analyze the ability of EAT thickness in predicting adverse cardiovascular (CV) events in AF. In 190 persistent AF patients, w …

Association of Volumetric Epicardial Adipose Tissue ...

Dec 04, 2018·Background. Epicardial adipose tissue (EAT) is in immediate apposition to the underlying myocardium and, therefore, has the potential to influence myocardial systolic and diastolic function or myocardial geometry, through paracrine or compressive mechanical effects.We aimed to review the association between volumetric EAT and markers of myocardial function and geometry.

Epicardial adipose tissue differentiates in patients with ...

Jun 25, 2021·Epicardial adipose tissue (EAT) is a visceral fat depot that shares direct anatomic contact with the myocardium without fascial interruption. …

Sglt2-Inhibitors On Epicardial Adipose Tissue | Encyclopedia

Mar 30, 2021·Definition. Sodium–glucose cotransporter-2 inhibitors (SGLT2-i) reduce adipose tissue and cardiovascular events in patients with type 2 diabetes (T2D). Accumulation of epicardial adipose tissue (EAT) is associated with increased cardio-metabolic risks and obstructive coronary disease events in patients with T2D.

Adipokine - an overview | ScienceDirect Topics

Juergen Eckel, in The Cellular Secretome and Organ Crosstalk, 2018. Crosstalk Between Epicardial Adipose Tissue and the Myocardium. Adipokine expression in EAT has been profiled using microarray analysis and real-time PCR in humans and antibody arrays in guinea pigs (Greulich et al. 2011, 2012; Dutour et al., 2010).All studies show changes in adipokine expression levels among the various fat ...

Association of Volumetric Epicardial Adipose Tissue ...

Nov 21, 2018·Increasing epicardial adipose tissue volume is associated with diastolic dysfunction, independent of other markers of adiposity. Epicardial adipose tissue is an effect modifier for left ventricle chamber geometry. Epicardial adipose tissue is not associated with systolic function.

Dysregulation of epicardial adipose tissue in cachexia due ...

Oct 20, 2020·In epicardial adipose tissue (EAT), expression of selected genes was evaluated, and a combined metabolomic/lipidomic analysis was performed to assess (i) the role of adipose tissue metabolism in the development of cachexia and (ii) potential impact of cachexia-associated changes on EAT-myocardium environment.

Adipose Tissue - Meaning, Types, Functions, and FAQs

The adipose tissue definition is as follows - it is a specialized connective tissue that helps in the storage of fat. These tissues are located in subcutaneous, intraabdominal, epicardial, and gonadal. These tissues are located in interscapular, perirenal, cervical, paravertebral and supraclavicular.

Epicardial Adipose Tissue Is Associated With Left Atrial ...

Aug 01, 2018·Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot. Although EAT volume is associated with the incidence and burden of atrial fibrillation (AF), its role in subclinical left atrial (LA) dysfunction is unclear. This study aims to evaluate the relationships between EAT volumes, LA function, and LA global longitudinal strain.

Epicardial Adipose Tissue: The Genetics Behind an Emerging ...

Jul 03, 2021·Epicardial adipose tissue (EAT) or epicardial fat, is often referred in the literature as a form of visceral fat located between the myocardial surface and the visceral layer of the pericardium, sharing a common embryologic origin with visceral fat deposits. 1 It should not be confused with pericardial fat, as they share different embryologic sources, blood supply, and represent a different ...

Adipogenesis and epicardial adipose tissue: A novel fate ...

Feb 17, 2015·epicardial adipose tissue; EAT; PPARγ; epicardium to mesenchymal transformation; The human heart is surrounded by an extensive layer of fat, and for centuries, the biology of this tissue has been debated without experimental resolution (1 ⇓ –3).This tissue lies underneath the epicardium (the outer mesothelial layer of the heart) and is termed epicardial adipose tissue, or EAT, based on ...

Epicardial adipose tissue thickness is not associated with ...

Apr 14, 2020·Epicardial adipose tissue (EAT) represents a real and unique visceral fat deposit of the heart in terms of the size of its adipocytes, biochemical composition, and metabolic activity.

Dysregulation of epicardial adipose tissue in cachexia due ...

In epicardial adipose tissue (EAT), expression of selected genes was evaluated, and a combined metabolomic/lipidomic analysis was performed to assess (i) the role of adipose tissue metabolism in the development of cachexia and (ii) potential impact of cachexia‐associated changes on …