connective tissue growth factor peptide

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Frontiers | Connective Tissue Growth Factor: From ...- connective tissue growth factor peptide ,Oct 29, 2020·Connective tissue growth factor protein contains 38 fully conserved cysteine residues, which are evenly spread throughout the protein (1 in signal peptide region, 11 in IGFBP, 10 in VWC, 6 in TSP1, and 10 in CT) except for a cysteine free-region between Asp167 and Asn198 (‘hinge region’) (Brigstock, 1999).A novel peptide isolated from phage display peptides ...Mar 01, 2009·Connective tissue growth factor (CTGF) is a novel profibrotic factor that is upregulated in different human diseases . Angiotensin II (AngII) could stimulate overexpression of CTGF and regulates renal fibrosis via type 1 angiotensin(AT1) receptor by the Smad signaling pathway , . CTGF was positive in the majority of human biopsy specimens from ...



CTGF antibody (Connective Tissue Growth Factor) Primary ...

CTGF (connective tissue growth factor) is a 38 kDa, cysteine-rich, secreted peptide. It is a new member of the peptide family that include serum-induced immediate early gene products, a v-src-induced peptide and a putative proto-oncogene. Among the many functions of the CTGF gene family are embryogenesis, wound healing and regulation of ...

Connective Tissue Growth Factor ELISA, IB07001 (RUO) | IBL ...

Connective Tissue Growth Factor (CTGF) Enzyme linked immunosorbent assay (ELISA) for the determination of human Connective Tissue Growth Factor in plasma (EDTA, citrate, heparin) and urine. For research use only, not for use in diagnostic procedures.

Connective Tissue Growth Factor | Arteriosclerosis ...

Aug 01, 1997·Abstract Connective tissue growth factor (CTGF) is a novel cysteine-rich, secreted peptide, which is implicated in human atherosclerosis and fibrotic disorders such as systemic sclerodermaTGF is a member of the peptide family that includes serum-induced immediate early gene products, a v-src–induced peptide…

Connective tissue growth factor mRNA expression is ...

Aug 01, 1998·connective tissue growth factor (CTGF) is a newly described fibroblast mitogen and promoter of collagen deposition. CTGF was first isolated from human umbilical artery endothelial cells and subsequently was found to be expressed by human foreskin and dermal fibroblasts but not by other cell types such as epithelial cells or leukocytes ().It is a 38-kDa, cysteine-rich peptide and shares ...

Increased connective tissue growth factor relative to ...

Excessive fibrosis contributes to an increase in left ventricular stiffness. The goal of the present study was to investigate the role of connective tissue growth …

NIOSHTIC-2 Publications Search - 20030981 - A peptide from ...

The present study was undertaken to investigate the therapeutic benefit of this TSP-1-derived peptide sequence and its effect on connective tissue growth factor (CTGF), a protein involved in fibrotic disorders and in neovascularization, which is a hallmark of RA.

Identification of glycosylated 38-kDa connective tissue ...

N2 - Connective Tissue Growth Factor (CTGF) is a cysteine-rich peptide involved in human atherosclerosis and fibrotic disorders such as scleroderma. CTGF has considerable N-terminal sequence similarity with the insulin-like growth factor binding proteins (IGFBPs), including preservation of cysteines, and has been postulated to be a member of ...

(PDF) A peptide from thrombospondin 1 modulates ...

The present study was undertaken to investigate the therapeutic benefit of this TSP-1-derived peptide sequence and its effect on connective tissue growth factor (CTGF), a protein involved in ...

CTGF - Wikipedia

CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, skeletal development, and tissue wound repair, and is ...

Connective Tissue Growth Factor Expression in Pediatric ...

Human connective tissue growth factor (CTGF) is a secreted cysteine-rich peptide and a member of the peptide family that includes serum-induced immediate gene products such as a v-src-induced peptide and a putative proto-oncogene, c-src. CTGF is secreted by endothelial cells, fibroblasts, smooth muscle cells, and myofibroblasts. Its expression is increased in various human and animal fibrotic ...

Therapeutic Potential of Pro-Resolving Mediators in ...

2 天前·High extracellular glucose and TGF-β1 stimulate the upregulation of connective tissue growth factor (CTGF/CCN2) in kidney mesangial and tubular epithelial cells, ... Inflammation resolution is mediated via a cascade of peptides and lipid mediators which restrict neutrophil recruitment to the site of tissue …

A peptide from thrombospondin 1 modulates experimental ...

Jul 25, 2006·The present study was undertaken to investigate the therapeutic benefit of this TSP‐1–derived peptide sequence and its effect on connective tissue growth factor (CTGF), a protein involved in fibrotic disorders and in neovascularization, which is a hallmark of RA.

Regulation of connective tissue growth factor gene ...

Apr 08, 2018·Connective tissue growth factor (CTGF) is a cysteine-rich peptide that exhibits platelet-derived growth factor (PDGF)-like biological and immunological activities. CTGF is a member of a family of peptides that include serum-induced immediate early gene products, a v-src-induced peptide, and a putative avian transforming gene, nov.

Connective tissue growth factor: a mediator of TGF-β ...

Connective tissue growth factor (CTGF) is a cysteine-rich mitogenic peptide that binds heparin and is secreted by fibroblasts after activation with transforming growth factor beta (TGF-β). CTGF is a member of a highly conserved family of peptides that include immediate early gene products cef10, cyr61, fisp12; a putative avian proto-oncogene ...

Connective tissue growth factor(CTGF) - University of ...

This previously unknown factor, termed Connective Tissue Growth Factor (CTGF), is related immunologically and biologically to PDGF, however it is the product of a distinct gene. In a first aspect, the present invention relates to a polypeptide growth factor for connective tissue cells.

Therapeutic Potential of Pro-Resolving Mediators in ...

2 天前·High extracellular glucose and TGF-β1 stimulate the upregulation of connective tissue growth factor (CTGF/CCN2) in kidney mesangial and tubular epithelial cells, ... Inflammation resolution is mediated via a cascade of peptides and lipid mediators which restrict neutrophil recruitment to the site of tissue …

N-terminal domains of CCN family 2/connective tissue ...

N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan Eriko Aoyama , Takako Hattori , Mitsuhiro Hoshijima , Daisuke Araki, Takashi …

Connective Tissue Growth Factor | Arteriosclerosis ...

Aug 01, 1997·Abstract Connective tissue growth factor (CTGF) is a novel cysteine-rich, secreted peptide, which is implicated in human atherosclerosis and fibrotic disorders such as systemic sclerodermaTGF is a member of the peptide family that includes serum-induced immediate early gene products, a v-src–induced peptide…

(PDF) Regulation of connective tissue growth factor ...

Connective tissue growth factor (CTGF) is a cysteine-rich peptide that exhibits platelet-derived growth factor (PDGF)-like biological and immunological activities.

Connective Tissue Growth Factor Expression in Pediatric ...

Human connective tissue growth factor (CTGF) is a secreted cysteine-rich peptide and a member of the peptide family that includes serum-induced immediate gene products such as a v-src-induced peptide and a putative proto-oncogene, c-src. CTGF is secreted by endothelial cells, fibroblasts, smooth muscle cells, and myofibroblasts. Its expression is increased in various human and animal fibrotic ...

Connective tissue growth factor: a mediator of TGF-β ...

Sep 01, 1997·Connective tissue growth factor (CTGF) is a cysteine-rich mitogenic peptide that binds heparin and is secreted by fibroblasts after activation with transforming …

Connective tissue growth factor(CTGF) - University of ...

This previously unknown factor, termed Connective Tissue Growth Factor (CTGF), is related immunologically and biologically to PDGF, however it is the product of a distinct gene. In a first aspect, the present invention relates to a polypeptide growth factor for connective tissue cells.

CTGF - Connective tissue growth factor - Homo sapiens ...

May 10, 2005·Connective tissue growth factor. Gene. CTGF. Organism. Homo sapiens (Human) Status. Unreviewed-Annotation score: -Experimental ... Signal peptide i: 1 – 26: Sequence analysis Add BLAST: 26 Chain i PRO_5014309868: 27 – 349: Sequence analysis Add BLAST: 323: Keywords ...

Increased Connective Tissue Growth Factor Relative to ...

Oct 19, 2020·高达10%返现·Human connective tissue growth factor (CTGF) is a secreted cysteine-rich peptide that stimulates cell proliferation, migration, and extracellular matrix production …

Connective tissue growth factor mediates transforming ...

Oct 01, 1999·Connective tissue growth factor (CTGF) is a cysteine-rich peptide synthesized and secreted by fibroblastic cells after activation with transforming growth factor beta (TGF-β) that acts as a downstream mediator of TGF-β-induced fibroblast proliferation.

Synchronous delivery of hydroxyapatite and connective ...

Here, a facile strategy comprising the incorporation of an osteogenic inductive peptide H1, derived from the cysteine knot (CT) domain of connective tissue …