adipose tissue lipolysis and glucose production

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Milestones in Molecular Mechanisms of Adipogenesis and ...- adipose tissue lipolysis and glucose production ,This leads to hypertrophic, dysfunctional and insulin-resistant adipose cells with a reduced content of GLUT4, the major insulin-regulated glucose transporter, which in turn reduces adipose tissue ...Partial Inhibition of Adipose Tissue Lipolysis Improves ...Feb 19, 2013·Partial inhibition of adipose tissue lipolysis does not increase fat mass but improves glucose metabolism and insulin sensitivity through modulation of fatty acid turnover and induction of …



Central Endocannabinoid Signaling Regulates Hepatic ...

Apr 01, 2011·With regards to adipose tissue, insulin resistance is defined as the inability of hyperinsulinemia to suppress lipolysis . Unrestrained lipolysis is an important contributor to the pathogenesis of type 2 diabetes since elevated free fatty acids induce lipotoxicity and further worsen insulin resistance ( 9 ).

Cytosolic lipolysis in non‐adipose tissues: energy ...

Aug 18, 2021·Adipose tissue lipolysis is enhanced by endurance training in mice and humans to meet the increased energy demand and may promote the occurrence of exercise-induced cardiac hypertrophy through the lipokine C16 : 1n7 palmitoleic acid []. Importantly, cytosolic lipolysis has a more direct role in heart.

Muscle and adipose tissue insulin resistance: malady ...

Oct 01, 2019·Under fasting conditions, hepatic glucose output and release of fatty acids from triacylglycerol (TAG) stores in adipose tissue (lipolysis) provide substrates for oxidation and ATP production. In the fed state, increases in circulating amino acids, fatty acids, and glucose stimulate insulin secretion.

Brain Insulin Controls Adipose Tissue Lipolysis and ...

Through its action on hypothalamus, insulin has systemic metabolic effects by suppressing hepatic glucose production [183], lipolysis in adipose tissue [184], and by decreasing food intake [185 ...

Adipose tissue lipolysis, plasma fatty acids, and glucose ...

Apr 01, 2021·Insulin is the key regulator of plasma glucose concentration, because it potently suppresses hepatic glucose production and stimulates tissue glucose uptake. Obesity is often associated with both insulin resistance and hyperinsulinemia. The concurrence of the two is commonly thought to reflect a homeostatic feedback loop in which the insulin resistance-mediated increase in plasma glucose ...

Lipid and glucose metabolism in white adipocytes: pathways ...

Feb 24, 2021·In skeletal muscle and white adipose tissue (WAT), insulin is less efficient in stimulating glucose uptake while, in the liver, the hormone loses its ability to inhibit endogenous glucose production.

Muscle and adipose tissue insulin resistance: malady ...

Oct 01, 2019·Under fasting conditions, hepatic glucose output and release of fatty acids from triacylglycerol (TAG) stores in adipose tissue (lipolysis) provide substrates for oxidation and ATP production. In the fed state, increases in circulating amino acids, fatty acids, and glucose stimulate insulin secretion.

Insulin and Rosiglitazone Regulation of Lipolysis and ...

Abstract. Lipolysis is an important process determining fuel metabolism, and insulin regulates this process in adipose tissue. The aim of this study was to investigate the long-term effects of insulin, an insulin enhancer (rosiglitazone [RSG]), and insulin in combination with RSG on the regulation of lipolysis and lipogenesis in human abdominal subcutaneous fat.

The role of adipose triglyceride lipase in lipid and ...

Nov 22, 2019·Circulating glucose and amino acids, as well as stored glycogen are a source for rapid ATP production in humans and other mammals, but constitute a relatively small pool of energy substrates with glucose and glycogen stores totalling approximately 1500 available kilocalories, compared to fat stored in adipose tissue, which can total ...

Brain Insulin Controls Adipose Tissue Lipolysis and ...

White adipose tissue (WAT) dysfunction plays a key role in the pathogenesis of type 2 diabetes (DM2). Unrestrained WAT lipolysis results in increased fatty acid …

RBP4 increases lipolysis in human adipocytes and is ...

Mar 13, 2020·Insulin resistance in obesity is a complex metabolic state consisting of increased endogenous glucose production (EGP), reduced muscle glucose uptake and increased lipolysis. 1 Many studies have now demonstrated low grade inflammation, systemically and in adipose tissue in the obese state 1 but the causal relationship between inflammation and ...

Glucose transporters in adipose tissue, liver, and ...

Jun 26, 2020·A family of facilitative glucose transporters (GLUTs) is involved in regulating tissue-specific glucose uptake and metabolism in the liver, skeletal muscle, and adipose tissue to ensure homeostatic control of blood glucose levels. Reduced glucose transport activity results in aberrant use of energy substrates and is associated with insulin resistance and type 2 diabetes. It is well established ...

Frontiers | Adipose Tissue Metabolic Function and ...

Oct 28, 2020·Adipose Tissue Lipolysis. Adipose tissue enacts lipolytic pathways when activated by external stimulus from the brain and adrenal glands during starvation mode, while exercising and when energy requirements are enhanced (Nielsen et al., 2014).Once lipolysis is activated, TAG reserves in adipocytes are broken down to glycerol and free fatty acids (FFA) that can be used when glucose reserves are ...

Whole-body and adipose tissue glucose metabolism in ...

Mar 01, 2001·Results of an assessment of adipose tissue interstitial lactate concentrations with use of microdialysis probes support the notion that adipose tissue is a major site for lactate production (35, 36), whereas data from arteriovenous lactate balance measurements across subcutaneous abdominal adipose tissue suggest that the contribution of adipose ...

Milestones in Molecular Mechanisms of Adipogenesis and ...

This leads to hypertrophic, dysfunctional and insulin-resistant adipose cells with a reduced content of GLUT4, the major insulin-regulated glucose transporter, which in turn reduces adipose tissue ...

Energy metabolism in brown adipose tissue - Wang - 2021 ...

May 24, 2021·Abstract. Brown adipose tissue (BAT) is well known to burn calories through uncoupled respiration, producing heat to maintain body temperature. This ‘calorie wasting’ feature makes BAT a special tissue, which can function as an ‘energy sink’ in mammals. While a combination of high energy intake and low energy expenditure is the leading ...

Milestones in Molecular Mechanisms of Adipogenesis and ...

This leads to hypertrophic, dysfunctional and insulin-resistant adipose cells with a reduced content of GLUT4, the major insulin-regulated glucose transporter, which in turn reduces adipose tissue ...

A beta cell ATGL-lipolysis/adipose tissue axis controls ...

Sep 27, 2016·Attané C, Daviaud D, Dray C et al (2011) Apelin stimulates glucose uptake but not lipolysis in human adipose tissue ex vivo. J Mol Endocrinol 46:21–28. Article CAS PubMed Google Scholar 27. Wicksteed B, Brissova M, Yan W et al (2010) Conditional gene targeting in …

Adipose tissue lipolysis, plasma fatty acids, and glucose ...

Apr 01, 2021·Insulin is the key regulator of plasma glucose concentration, because it potently suppresses hepatic glucose production and stimulates tissue glucose uptake.

The glucose-fatty acid cycle. Relationship between glucose ...

DOI: 10.1093/BJA/53.2.123 Corpus ID: 28935324. The glucose-fatty acid cycle. Relationship between glucose utilization in muscle, fatty acid oxidation in muscle and lipolysis in adipose tissue.

Adrenergic Regulation of Adipose Tissue Lipolysis in ...

Goals / Objectives Objective 1: To probe one mechanism of control of lipid metabolism in dairy cattle across a range of parities, feed intakes and milk production rates by examining expression of key genes in adipose tissue. Objective 2. To probe the mechanisms involved in regulation of lipogenesis, including insulin sensitive and non-sensitive systems by examining expression of key genes in ...

Oral 3‐hydroxybutyrate ingestion decreases endogenous ...

Aug 14, 2020·We quantified lipolysis and endogenous glucose production using [9,10‐ 3 H]‐palmitate and [3‐3H]glucose tracers, and adipose tissue biopsies were collected to investigate key lipolytic enzymes. Results

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The effects of Astragaloside IV on lipolysis and hepatic glucose production were investigated. Results: HFD feeding induced cAMP accumulation through reducing PDE3B expression and activity in adipose tissue. As a result, HFD feeding increased adipose lipolysis in mice.

A beta cell ATGL-lipolysis/adipose tissue axis controls ...

Sep 27, 2016·Attané C, Daviaud D, Dray C et al (2011) Apelin stimulates glucose uptake but not lipolysis in human adipose tissue ex vivo. J Mol Endocrinol 46:21–28. Article CAS PubMed Google Scholar 27. Wicksteed B, Brissova M, Yan W et al (2010) Conditional gene targeting in …

Insulin and Lipolysis | Healthfully

Jul 18, 2017·Insulin inhibits lipolysis and slows the breakdown of adipose tissue. This has important implications if you have type 2 diabetes or prediabetes. With these conditions, your body resists the action of insulin. Your pancreas tries to compensate by producing excessive amounts of insulin -- …

Adipose tissue in health and disease | Open Biology

Dec 09, 2020·5. Adipose tissue lipolysis and insulin resistance. Insulin resistance and the progression to type 2 diabetes are among the most common metabolic syndrome co-morbidities associated with obesity [83,118]. AT contributions to systemic insulin resistance have been previously addressed and are discussed throughout this review, but insulin ...